Endocrine Abstracts

Leptin is best known as an appetite and metabolic rate modulator secreted from fat, but it also has a range of other functions including modulation in reproductive physiology. To date, most studies examining the role of leptin in male reproduction have focussed on individual tissues, often in vitro. In the current report, a bolus physiological dose of iodinated leptin was administered intravenously to male mice to and samples collected over a one hour time course to d...

Introduction: Graves’ disease during pregnancy may cause maternal or neonatal complications, including arrhythmia, thyroid storm, congenital anomalies and neonatal thyroid dysfunction (TD). The optimal timing and frequency of TRAb measurement in pregnant women with a history of TD, and whether fetal monitoring could be limited to those with a strongly positive TRAb, is unclear.Methods: Retrospective case note review of women with elevated TRAb (>1 i...